BDBM50336048 1-methyl-6-(4-(2-(1-(methylsulfonyl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile::CHEMBL1669282

SMILES Cn1cnc2c(nc(cc12)-c1ccc(OCCC2CCN(CC2)S(C)(=O)=O)c(c1)C(F)(F)F)C#N

InChI Key InChIKey=LQFGGDAIICQKPL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50336048   

TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336048(1-methyl-6-(4-(2-(1-(methylsulfonyl)piperidin-4-yl...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336048(1-methyl-6-(4-(2-(1-(methylsulfonyl)piperidin-4-yl...)
Affinity DataIC50: 353nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as accumulation of lip10 by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336048(1-methyl-6-(4-(2-(1-(methylsulfonyl)piperidin-4-yl...)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336048(1-methyl-6-(4-(2-(1-(methylsulfonyl)piperidin-4-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336048(1-methyl-6-(4-(2-(1-(methylsulfonyl)piperidin-4-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human cathepsin VMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50336048(1-methyl-6-(4-(2-(1-(methylsulfonyl)piperidin-4-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed