BDBM50335938 (3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(piperidin-1-yl)methanone::CHEMBL495528::US9339486, 3

SMILES CC1(Cc2ccccc2)COc2cc(ccc12)C(=O)N1CCCCC1

InChI Key InChIKey=ZEMCXAZYSOBAGF-UHFFFAOYSA-N

Data  8 KI  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50335938   

TargetCannabinoid receptor 2(Human)
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM50335938((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...)
Affinity DataEC50:  160nMAssay Description:Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2017
Entry Details
Go to US Patent

TargetCannabinoid receptor 1(Human)
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM50335938((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...)
Affinity DataEC50: >1.00E+4nMAssay Description:Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2017
Entry Details
Go to US Patent

TargetCannabinoid receptor 2(Human)
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM50335938((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...)
Affinity DataEC50:  128nMAssay Description:Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2017
Entry Details
Go to US Patent

TargetCannabinoid receptor 1(Rat)
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM50335938((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...)
Affinity DataEC50: >1.00E+4nMAssay Description:The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2017
Entry Details
Go to US Patent

TargetCannabinoid receptor 2(Rat)
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM50335938((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...)
Affinity DataEC50:  21.7nMAssay Description:The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2017
Entry Details
Go to US Patent

TargetCannabinoid receptor 2(Rat)
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM50335938((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...)
Affinity DataKi:  238nMAssay Description:Displacement of [3H]-CP55940 from rat CB2 receptor expressed in CHO-K1 cells by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM50335938((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...)
Affinity DataKi:  422nMpH: 7.4Assay Description:Cell membrane homogenates (15 μg protein) were incubated for 120 min at 37° C. with 0.8 nM [3H]WIN 55212-2 (the reference standard [Munro, 1993 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2017
Entry Details
Go to US Patent

TargetCannabinoid receptor 2(Human)
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM50335938((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...)
Affinity DataKi:  422nMAssay Description:Displacement of [3H]-CP55940 from human CB2 receptor expressed in CHO-K1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM50335938((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...)
Affinity DataKi:  422nMAssay Description:Displacement of [3H]CP 55940 from human CB2 receptor in cell free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM50335938((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...)
Affinity DataKi:  2.57E+3nMAssay Description:Displacement of [3H]SR141716A from rat CB1 receptor expressed in CHO-K1 cells by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM50335938((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...)
Affinity DataKi: >1.00E+4nMpH: 7.4Assay Description:Cell membrane homogenates (25 μg protein) were incubated for 120 min at 37° C. with 0.5 nM [3H]CP 55940 (the reference standard [Rinaldi-Carmona...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2017
Entry Details
Go to US Patent

TargetCannabinoid receptor 1(Human)
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM50335938((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-CP55940 from human CB1 receptor expressed in CHO-K1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM50335938((3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-yl)(pip...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]CP 55940 from human CB1 receptor in cell free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed