BDBM503356 5-(2,3-Dichloro-phenyl)-6-methyl-2- (5-methyl-hexahydro-pyrrolo[3,4- c]pyrrol-2-yl)-pyrimidine-4- carboxylic acid amide::US11033547, Compound 56::US11696916, Compound 56

SMILES CN1CC2CN(CC2C1)c1nc(C)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O

InChI Key InChIKey=KETZUNJWEVGBTA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503356   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503356(5-(2,3-Dichloro-phenyl)-6-methyl-2- (5-methyl-hexa...)
Affinity DataIC50: 960nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503356(5-(2,3-Dichloro-phenyl)-6-methyl-2- (5-methyl-hexa...)
Affinity DataIC50: 960nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent