BDBM50335460 1-((6-(5-cyclohexylbenzofuran-2-yl)pyridin-3-yl)methyl)azetidine-3-carboxylic acid::CHEMBL1651715

SMILES OC(=O)C1CN(Cc2ccc(nc2)-c2cc3cc(ccc3o2)C2CCCCC2)C1

InChI Key InChIKey=UUONBZVZZSPSJA-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50335460   

TargetSphingosine 1-phosphate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335460(1-((6-(5-cyclohexylbenzofuran-2-yl)pyridin-3-yl)me...)
Affinity DataEC50:  720nMAssay Description:Agonist activity at human S1P1R expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335460(1-((6-(5-cyclohexylbenzofuran-2-yl)pyridin-3-yl)me...)
Affinity DataEC50:  424nMAssay Description:Induction of human GFP-tagged chimeric S1P1R internalization in human U2Os cells by fluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335460(1-((6-(5-cyclohexylbenzofuran-2-yl)pyridin-3-yl)me...)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human S1P3R expressed in CHO cells by Ca(2+) mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed