BDBM50335376 (S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-hexahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione::(S,Z)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-hexahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione::CHEMBL1651523

SMILES COc1cc(O)c2c(CCCCCC(=O)C=CC[C@H](C)OC2=O)c1

InChI Key InChIKey=JWTUFAOHKVRJNA-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50335376   

LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RET by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human recombinant MEK1 expressed in insect cells after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant VEGFR2 expressed in Sf9 cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 850nMAssay Description:Inhibition of human recombinant FLT-3 kinase expressed in insect cells after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of human recombinant PDGFRbeta expressed in insect cells after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 440nMAssay Description:Inhibition of human recombinant PDGFRalpha in cell free system after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of human recombinant c-kit kinase in cell free system after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant VEGFR1 expressed in Sf9 cells after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of VEGFR2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TYK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of ALK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MNK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MK5 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 6.84E+3nMAssay Description:Inhibition of MEK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LCK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cKIT by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EPHB4 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERK2 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50335376((S)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human recombinant VEGFR3 in cell free system after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed