BDBM50335202 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine::CHEMBL1650723

SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)[nH]n1

InChI Key InChIKey=KWKMYGPZQBMLGC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50335202   

TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335202(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK3 using 5 mM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335202(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 using Km ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335202(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 108nMAssay Description:Inhibition of JAK2 using 5 mM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50335202(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human JAK2 (808 to end residues) expressed in baculovirus infected SF21 insect cells using Tyr 1054/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed