BDBM50335188 CHEMBL1650545::CHEMBL1650551::N-[3-[(3,3-Difluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride

SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCC(F)(F)C3)ns2)n1)-c1cn[nH]c1

InChI Key InChIKey=JVAFTPDILUBIGR-UHFFFAOYSA-N

Data  48 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 48 hits for monomerid = 50335188   

TargetTyrosine-protein kinase JAK2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 550nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 700nMAssay Description:Inhibition of EPHB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 46nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 640nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 340nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 470nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type IV(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CAMK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of MST2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of RSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTestis-specific serine/threonine-protein kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of TSSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CSNK1DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 640nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of MST2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PKCAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PKCAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of RSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 91nMAssay Description:Inhibition of Aurora B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTestis-specific serine/threonine-protein kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of TSSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 63nMAssay Description:Inhibition of Aurora B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type IV(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CAMK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 770nMAssay Description:Inhibition of EPHB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 76nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CSNK1DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 100nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650551 | CHEMBL1650545 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: 2.35E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed