BDBM50334483 CHEMBL1644186::N-((2H-tetrazol-5-yl)methyl)-4-((3-(3,5-dichlorophenyl)-5-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-1-yl)methyl)benzamide

SMILES FC(F)(F)Oc1ccc(cc1)-c1cc(nn1Cc1ccc(cc1)C(=O)NCc1nnn[nH]1)-c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=NCKNXZMACSRNIH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50334483   

TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334483(N-((2H-tetrazol-5-yl)methyl)-4-((3-(3,5-dichloroph...)
Affinity DataIC50: 650nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGastric inhibitory polypeptide receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334483(N-((2H-tetrazol-5-yl)methyl)-4-((3-(3,5-dichloroph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334483(N-((2H-tetrazol-5-yl)methyl)-4-((3-(3,5-dichloroph...)
Affinity DataIC50: 120nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed