BDBM50334481 3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-1-yl)methyl)benzamido)propanoic acid::CHEMBL1644183

SMILES OC(=O)CCNC(=O)c1ccc(Cn2nc(cc2-c2ccc(OC(F)(F)F)cc2)-c2cc(Cl)cc(Cl)c2)cc1

InChI Key InChIKey=IGCXZPHCSPIQHB-UHFFFAOYSA-N

Data  16 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50334481   

TargetPituitary adenylate cyclase-activating polypeptide type I receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 7.00E+3nMAssay Description:Antagonist activity at human PACAPR1 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 114nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGastric inhibitory polypeptide receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 6.28E+3nMAssay Description:Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataEC50: >2.50E+4nMAssay Description:Activity at human PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP2C8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 84nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 2.60E+3nMAssay Description:Antagonist activity at rat GCGR assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at mouse GCGR assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGastric inhibitory polypeptide receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 7.50E+3nMAssay Description:Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 86nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cells after 3 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetUncharacterized protein [173-650](Dog)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at dog GCGR assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human GLP1R expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed