BDBM50334366 CHEMBL1643308::N-(2-aminophenyl)-3-(4-(1-(2-morpholinoethylamino)-2-oxo-2-(4-(trifluoromethyl)phenylamino)ethyl)phenyl)acrylamide

SMILES Nc1ccccc1NC(=O)\C=C\c1ccc(cc1)C(NCCN1CCOCC1)C(=O)Nc1ccc(cc1)C(F)(F)F

InChI Key InChIKey=APFIGEZLZRKKKP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50334366   

TargetHistone deacetylase 1(Human)
Roche R & D Center China

Curated by ChEMBL
LigandPNGBDBM50334366(N-(2-aminophenyl)-3-(4-(1-(2-morpholinoethylamino)...)
Affinity DataIC50: 60nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Roche R & D Center China

Curated by ChEMBL
LigandPNGBDBM50334366(N-(2-aminophenyl)-3-(4-(1-(2-morpholinoethylamino)...)
Affinity DataIC50: 290nMAssay Description:Inhibition of HDAC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Roche R & D Center China

Curated by ChEMBL
LigandPNGBDBM50334366(N-(2-aminophenyl)-3-(4-(1-(2-morpholinoethylamino)...)
Affinity DataIC50: 460nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Roche R & D Center China

Curated by ChEMBL
LigandPNGBDBM50334366(N-(2-aminophenyl)-3-(4-(1-(2-morpholinoethylamino)...)
Affinity DataIC50: 60nMAssay Description:Inhibition of HDAC1 using p53 (379 to 382 residues) based fluorogenic peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed