BDBM50334179 5-(naphthalen-1-ylmethylene)thiazolidine-2,4-dione::CHEMBL1348329::US10278929, Compound 13::US11337935, Compound 13

SMILES O=C1NC(=O)\C(S1)=C\c1cccc2ccccc12

InChI Key InChIKey=WMHVUSFNJBJQQB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50334179   

TargetTransthyretin(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM50334179(5-(naphthalen-1-ylmethylene)thiazolidine-2,4-dione...)
Affinity DataIC50: 842nMAssay Description:The FP assay was then adapted for HTS and used to screen ~120,000 small molecule library for compounds that displaced probe 5 from the T4 binding of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2015
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member B1(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50334179(5-(naphthalen-1-ylmethylene)thiazolidine-2,4-dione...)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTransthyretin(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM50334179(5-(naphthalen-1-ylmethylene)thiazolidine-2,4-dione...)
Affinity DataIC50: 842nMAssay Description:The FP assay was then adapted for HTS and used to screen a 120,000 member small molecule library for compounds that displaced the FP probe from the T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member B1(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50334179(5-(naphthalen-1-ylmethylene)thiazolidine-2,4-dione...)
Affinity DataIC50: 8.95E+3nMAssay Description:Inhibition of aldose reductase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetAldo-keto reductase family 1 member B1(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50334179(5-(naphthalen-1-ylmethylene)thiazolidine-2,4-dione...)
Affinity DataIC50: 8.95E+3nMAssay Description:Inhibition of aldose reductase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetTransthyretin(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM50334179(5-(naphthalen-1-ylmethylene)thiazolidine-2,4-dione...)
Affinity DataIC50: 842nMAssay Description:Table 3: The FP assay was then adapted for HTS and used to screen 120,000 small molecule library for compounds that displaced probe 5 from the T4 bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
Go to US Patent