BDBM50334158 1'-benzyl-3-(2-fluoroethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine::CHEMBL1645202::CHEMBL2314421

SMILES FCCC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12

InChI Key InChIKey=LDFPQKADFLEDQV-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50334158   

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50334158(CHEMBL2314421 | CHEMBL1645202 | 1'-benzyl-3-(2-flu...)
Affinity DataKi:  0.590nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334158(CHEMBL2314421 | CHEMBL1645202 | 1'-benzyl-3-(2-flu...)
Affinity DataKi:  0.590nMAssay Description:Binding affinity to sigma 1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50334158(CHEMBL2314421 | CHEMBL1645202 | 1'-benzyl-3-(2-flu...)
Affinity DataKi:  0.590nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain homogenates after 180 mins by solid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
Institute of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50334158(CHEMBL2314421 | CHEMBL1645202 | 1'-benzyl-3-(2-flu...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to VAChTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Human)
Institute of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50334158(CHEMBL2314421 | CHEMBL1645202 | 1'-benzyl-3-(2-flu...)
Affinity DataKi:  211nMAssay Description:Binding affinity to EBPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetVesicular acetylcholine transporter(Human)
Institute of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50334158(CHEMBL2314421 | CHEMBL1645202 | 1'-benzyl-3-(2-flu...)
Affinity DataKi:  211nMAssay Description:Binding affinity to VAChT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50334158(CHEMBL2314421 | CHEMBL1645202 | 1'-benzyl-3-(2-flu...)
Affinity DataKi:  372nMAssay Description:Displacement of radioligand from kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50334158(CHEMBL2314421 | CHEMBL1645202 | 1'-benzyl-3-(2-flu...)
Affinity DataKi:  372nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50334158(CHEMBL2314421 | CHEMBL1645202 | 1'-benzyl-3-(2-flu...)
Affinity DataKi:  456nMAssay Description:Displacement of radioligand from mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50334158(CHEMBL2314421 | CHEMBL1645202 | 1'-benzyl-3-(2-flu...)
Affinity DataKi:  456nMAssay Description:Binding affinity to mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Institute of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50334158(CHEMBL2314421 | CHEMBL1645202 | 1'-benzyl-3-(2-flu...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to delta opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetEmopamil-binding protein-like(Human)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50334158(CHEMBL2314421 | CHEMBL1645202 | 1'-benzyl-3-(2-flu...)
Affinity DataKi:  1.40E+3nMAssay Description:Binding affinity to emopamil binding protein (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed