BDBM50334128 (S)-4-(1-(1-(3-(trifluoromethyl)benzyl)indoline-7-carboxamido)ethyl)benzoic acid::CHEMBL1645138

SMILES C[C@H](NC(=O)c1cccc2CCN(Cc3cccc(c3)C(F)(F)F)c12)c1ccc(cc1)C(O)=O

InChI Key InChIKey=CFOAEZFHQAAHLX-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50334128   

TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50334128((S)-4-(1-(1-(3-(trifluoromethyl)benzyl)indoline-7-...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as potentiation of PGE2-induced cAMP accumulation by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50334128((S)-4-(1-(1-(3-(trifluoromethyl)benzyl)indoline-7-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50334128((S)-4-(1-(1-(3-(trifluoromethyl)benzyl)indoline-7-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed