BDBM50334089 2-[5-Chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide::CHEMBL1644809

SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3CCCC(=O)Nc3c2)ncc1Cl

InChI Key InChIKey=YJFOJLPHZMITIB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50334089   

TargetHepatocyte growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50334089(2-[5-Chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b...)
Affinity DataIC50: 99nMAssay Description:Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50334089(2-[5-Chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b...)
Affinity DataIC50: 30nMAssay Description:Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50334089(2-[5-Chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b...)
Affinity DataIC50: 30nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50334089(2-[5-Chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b...)
Affinity DataIC50: 99nMAssay Description:Inhibition of human c-Met in human GTL16 cells by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50334089(2-[5-Chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b...)
Affinity DataIC50: 369nMAssay Description:Inhibition of IR kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed