BDBM50334055 5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1,2,3,4-tetrahydroquinolin-3-ol::CHEMBL1644761

SMILES Cc1cc(c(Cl)c2c1NC(C)(C)C(O)C2(C)C)-c1cccc2cc[nH]c12

InChI Key InChIKey=VWTXAIVZMCQYKU-UHFFFAOYSA-N

Data  4 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50334055   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334055(5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1...)
Affinity DataEC50:  105nMAssay Description:Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with GRE assessed as transactivation activity by luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334055(5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1...)
Affinity DataIC50: 14nMAssay Description:Transrepression activity at glucocorticoid receptor in TNFalpha/IL1beta-stimulated human HepG2 cells assessed as inhibition of NFkappaB-dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334055(5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1...)
Affinity DataIC50: 37nMAssay Description:Transrepression activity at glucocorticoid receptor in IL-1beta-stimulated human HepG2 cells assessed as inhibition of AP1 response element-induced I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334055(5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1...)
Affinity DataKi:  16nMAssay Description:Displacement of radiolabeled Dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334055(5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1...)
Affinity DataKi:  890nMAssay Description:Binding affinity to mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334055(5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1...)
Affinity DataKi:  915nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334055(5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1...)
Affinity DataKi:  1.30E+3nMAssay Description:Binding affinity to progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed