BDBM50334052 5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-4-(3-methylbut-2-enyl)-1,2-dihydroquinolin-3(4H)-one::CHEMBL1644757

SMILES CC(C)=CCC1(C)C(=O)C(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12

InChI Key InChIKey=VPGLREFJYMSJHR-UHFFFAOYSA-N

Data  2 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50334052   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334052(5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-4-(...)
Affinity DataEC50:  215nMAssay Description:Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with GRE assessed as transactivation activity by luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334052(5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-4-(...)
Affinity DataIC50: 18nMAssay Description:Transrepression activity at glucocorticoid receptor in TNFalpha/IL1beta-stimulated human HepG2 cells assessed as inhibition of NFkappaB-dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334052(5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-4-(...)
Affinity DataIC50: 64nMAssay Description:Transrepression activity at glucocorticoid receptor in IL-1beta-stimulated human HepG2 cells assessed as inhibition of AP1 response element-induced I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334052(5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-4-(...)
Affinity DataKi:  6nMAssay Description:Displacement of radiolabeled Dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334052(5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-4-(...)
Affinity DataKi:  420nMAssay Description:Binding affinity to progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed