BDBM50334050 5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1,2-dihydroquinolin-3(4H)-one::CHEMBL1644755

SMILES Cc1cc(c(Cl)c2c1NC(C)(C)C(=O)C2(C)C)-c1cccc2cc[nH]c12

InChI Key InChIKey=FAZOJHMTURPXLD-UHFFFAOYSA-N

Data  2 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50334050   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334050(5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1...)
Affinity DataIC50: 4.70nMAssay Description:Transrepression activity at glucocorticoid receptor in TNFalpha/IL1beta-stimulated human HepG2 cells assessed as inhibition of NFkappaB-dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334050(5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1...)
Affinity DataEC50:  95nMAssay Description:Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with GRE assessed as transactivation activity by luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334050(5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1...)
Affinity DataKi:  4.5nMAssay Description:Displacement of radiolabeled Dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50334050(5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1...)
Affinity DataKi:  14nMAssay Description:Binding affinity to progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed