BDBM50333651 4-oxo-N-phenyl-4H-chromene-3-carboxamide::CHEMBL1643120

SMILES O=C(Nc1ccccc1)c1coc2ccccc2c1=O

InChI Key InChIKey=NVUUCSMDDBUOOH-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50333651   

TargetAmine oxidase [flavin-containing] B(Human)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50333651(4-oxo-N-phenyl-4H-chromene-3-carboxamide | CHEMBL1...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant MAOB expressed in baculovirus-infected BTI insect cells after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50333651(4-oxo-N-phenyl-4H-chromene-3-carboxamide | CHEMBL1...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human MAO-B assessed as inhibition of p-tyramine oxidation to p-hydroxyphenyl-acetaldehyde after 15 mins by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50333651(4-oxo-N-phenyl-4H-chromene-3-carboxamide | CHEMBL1...)
Affinity DataIC50: 71nMAssay Description:Inhibition of human microsomal MAO-B expressed in recombinant baculovirus infected insect BTI-TN-5B1-4 cells assessed as reduction in H2O2 production...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50333651(4-oxo-N-phenyl-4H-chromene-3-carboxamide | CHEMBL1...)
Affinity DataKi:  8.51E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed