BDBM50333497 2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanamido)-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetic acid::CHEMBL1641811

SMILES C[C@@H](C(=O)N(C)[C@@H]1CCc2c(CC(O)=O)c3cccnc3n2C1)c1ccc(F)cc1

InChI Key InChIKey=YCLHCCNXVIOFPI-UHFFFAOYSA-N

Data  3 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50333497   

TargetProstaglandin D2 receptor 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333497(2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanami...)
Affinity DataIC50: 5.70nMAssay Description:Antagonist activity at human CRTH2 expressed in HEK293 cells assessed as inhibition of forskolin-induced increase intracellular [125I]cAMP level by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333497(2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanami...)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at CRTH2 in human eosinophil assessed as effect of cellular shape change by EOS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333497(2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanami...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333497(2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanami...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333497(2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanami...)
Affinity DataKi:  3.40nMAssay Description:Displacement of radioligand from human CRTH2 expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333497(2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanami...)
Affinity DataKi: >3.80E+4nMAssay Description:Displacement of radioligand from prostanoid DP receptor expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333497(2-((R)-8-((R)-2-(4-fluorophenyl)-N-methylpropanami...)
Affinity DataKi: >7.10E+4nMAssay Description:Displacement of radioligand from prostanoid TP receptor expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed