BDBM50333161 2-(4-Methylphenyl)-9-(2-phenylethyl)-2,6-dihydro[1,2,4]-triazolo[4,3-c]-quinazoline-3,5-dione::CHEMBL1644825

SMILES Cc1ccc(cc1)-n1nc2c3cc(CCc4ccccc4)ccc3[nH]c(=O)n2c1=O

InChI Key InChIKey=OEIRQQZGARGKRG-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50333161   

LigandPNGBDBM50333161(2-(4-Methylphenyl)-9-(2-phenylethyl)-2,6-dihydro[1...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]flumazenil human recombinant alpha1beta3gamma2 GABA(A) receptor expressed in HEK293 cells after 30 mins by glass fiber filtration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333161(2-(4-Methylphenyl)-9-(2-phenylethyl)-2,6-dihydro[1...)
Affinity DataKi:  9.70nMAssay Description:Displacement of [3H]flumazenil human recombinant alpha3beta3gamma2 GABA(A) receptor expressed in HEK293 cells after 30 mins by glass fiber filtration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Lund University

Curated by ChEMBL
LigandPNGBDBM50333161(2-(4-Methylphenyl)-9-(2-phenylethyl)-2,6-dihydro[1...)
Affinity DataKi:  65nMAssay Description:Displacement of [3H]flumazenil human recombinant alpha2beta3gamma2 GABA(A) receptor expressed in HEK293 cells after 30 mins by glass fiber filtration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Lund University

Curated by ChEMBL
LigandPNGBDBM50333161(2-(4-Methylphenyl)-9-(2-phenylethyl)-2,6-dihydro[1...)
Affinity DataKi:  66nMAssay Description:Displacement of [3H]flumazenil human recombinant alpha5beta3gamma2 GABA(A) receptor expressed in HEK293 cells after 30 mins by glass fiber filtration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed