BDBM50332991 4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one::CHEMBL261288

SMILES Fc1ccccc1-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnn1

InChI Key InChIKey=KQAQQTRQYSXKHD-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50332991   

TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332991(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at rat mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332991(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)
Affinity DataIC50: 12nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332991(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332991(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332991(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)
Affinity DataIC50: 16nMAssay Description:Displacement of [3H]LY354740 from recombinant rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332991(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332991(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)
Affinity DataIC50: 16nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332991(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)
Affinity DataIC50: 42nMAssay Description:Antagonist activity at rat mGluR3 expressed in CHO cells assessed as inhibition of glutamate-induced GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332991(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at rat mGluR2 expressed in CHO cells assessed as inhibition of glutamta-induced GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332991(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at rat mGluR2 assessed as blockade of (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed