BDBM50332990 4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)ethynyl)-7-hydroxy-1H-benzo[b][1,4]diazepin-2(3H)-one::4-(3-(1H-imidazol-1-yl)phenyl)-8-(2-(4-fluorophenyl)ethynyl)-7-hydroxy-1H-benzo[b][1,4]diazepin-2(3H)-one::CHEMBL411440

SMILES Oc1cc2N=C(CC(=O)Nc2cc1C#Cc1ccc(F)cc1)c1cccc(c1)-n1ccnc1

InChI Key InChIKey=RFKFAFMEFPSHAN-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50332990   

TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332990(4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332990(4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)...)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at rat mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332990(4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)...)
Affinity DataIC50: 26nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332990(4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)...)
Affinity DataIC50: 26nMAssay Description:Displacement of [3H]LY354740 from recombinant rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332990(4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)...)
Affinity DataIC50: 26nMAssay Description:Displacement of [3H]LY354740 from rat recombinant mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332990(4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at rat mGluR2 assessed as effect on (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332990(4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)...)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at rat mGluR2 expressed in CHO cells assessed as inhibition of glutamta-induced GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332990(4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)...)
Affinity DataIC50: 26nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332990(4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at rat mGluR2 assessed as blockade of (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed