BDBM50332989 4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one::CHEMBL1629861

SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-c1ccncc1

InChI Key InChIKey=JYTRCRINABXASK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50332989   

TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332989(4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-...)
Affinity DataIC50: 10nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332989(4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-...)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332989(4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-...)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332989(4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-...)
Affinity DataIC50: 52nMAssay Description:Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332989(4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-...)
Affinity DataIC50: 101nMAssay Description:Antagonist activity at rat mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed