BDBM50332969 7-methyl-4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one::CHEMBL1631858

SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1ccncc1

InChI Key InChIKey=ZYGZDPKEZBLAHD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50332969   

TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332969(7-methyl-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...)
Affinity DataIC50: 4nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332969(7-methyl-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50332969(7-methyl-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed