BDBM503329 6-amino-2-[4-amino-4- (hydroxymethyl)piperidin-1-yl]-5- (2,3-dichlorophenyl)-pyrimidine-4- carboxamide::US11033547, Compound 29::US11696916, Compound 29

SMILES NC(=O)c1nc(nc(N)c1-c1cccc(Cl)c1Cl)N1CCC(N)(CO)CC1

InChI Key InChIKey=GRYLRGGHJLSQTD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503329   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503329(6-amino-2-[4-amino-4- (hydroxymethyl)piperidin-1-y...)
Affinity DataIC50: 260nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503329(6-amino-2-[4-amino-4- (hydroxymethyl)piperidin-1-y...)
Affinity DataIC50: 260nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent