BDBM50332645 1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyrazole-3,5-dicarboxamide::CHEMBL1631095

SMILES NC(=O)c1cc(C(N)=O)n(n1)-c1cccc(c1)-c1cc(ccc1C(F)(F)F)C(F)(F)F

InChI Key InChIKey=MIGUNWYRDMCMDZ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50332645   

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 810nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 2.03E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 2.50E+4nMAssay Description:Induction of PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of Nav1.5 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 2.00E+6nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed