BDBM50332604 CHEMBL1630788::cis-N-Methyl-N-(4-methyl-1-(2,2,2-trifluoroethylsulfonyl)-piperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)S(=O)(=O)CC(F)(F)F

InChI Key InChIKey=IQGBQQYFBCFKHW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50332604   

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332604(cis-N-Methyl-N-(4-methyl-1-(2,2,2-trifluoroethylsu...)
Affinity DataIC50: 2.78E+3nMAssay Description:Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332604(cis-N-Methyl-N-(4-methyl-1-(2,2,2-trifluoroethylsu...)
Affinity DataIC50: 790nMAssay Description:Inhibition of GST-tagged human JAK2 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332604(cis-N-Methyl-N-(4-methyl-1-(2,2,2-trifluoroethylsu...)
Affinity DataIC50: 14nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed