BDBM50332599 CHEMBL1630770::N-Cyclohexyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

SMILES CN(C1CCCCC1)c1ncnc2[nH]ccc12

InChI Key InChIKey=UCOZXARHJOLLFO-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50332599   

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332599(N-Cyclohexyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332599(N-Cyclohexyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4...)
Affinity DataIC50: 160nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50332599(N-Cyclohexyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of human JAK2 using poly[Glu:Tyr] as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50332599(N-Cyclohexyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4...)
Affinity DataKd:  5.50E+4nMAssay Description:Binding affinity to N-terminal His tagged human recombinant JAK2 (1014 to 1132 residues) expressed in Escherichia coli after 60 to 90 mins by LC/MS a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332599(N-Cyclohexyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4...)
Affinity DataIC50: 79nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50332599(N-Cyclohexyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human Lck using TK-substrate-biotin as substrate incubated for 60 mins in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed