BDBM50332549 (S)-N-(4-(4-(5-isopropoxypyridin-2-yloxy)phenyl)butan-2-yl)acetamide::CHEMBL1630714::US8470841, 31

SMILES CC(C)Oc1ccc(Oc2ccc(CC[C@H](C)NC(C)=O)cc2)nc1

InChI Key InChIKey=NGIUAGMCGCGBQN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50332549   

TargetAcetyl-CoA carboxylase 2 [151-2458](Human)
Sanofi

US Patent
LigandPNGBDBM50332549(US8470841, 31 | CHEMBL1630714 | (S)-N-(4-(4-(5-iso...)
Affinity DataIC50: 200nMpH: 7.5 T: 2°CAssay Description:The reaction mixture contained 50 mM tris acetate (Merck, #1.08382.1000), pH 7.5, 250 μM acetyl coenzyme A (Sigma, #A2181),16 mM NaHCO3 (Merck, #1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2013
Entry Details
Go to US Patent

TargetAcetyl-CoA carboxylase 1(Rat)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50332549(US8470841, 31 | CHEMBL1630714 | (S)-N-(4-(4-(5-iso...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of N-terminal His-tagged rat recombinant ACC1 expressed in high five insect cells by ATP consumption assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50332549(US8470841, 31 | CHEMBL1630714 | (S)-N-(4-(4-(5-iso...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant ACC1 expressed in high five insect cells by ATP consumption assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50332549(US8470841, 31 | CHEMBL1630714 | (S)-N-(4-(4-(5-iso...)
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant ACC1 expressed in high five insect cells by ATP consumption assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 2(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50332549(US8470841, 31 | CHEMBL1630714 | (S)-N-(4-(4-(5-iso...)
Affinity DataIC50: 200nMAssay Description:Inhibition of N-terminal His-tagged human recombinant ACC2 expressed in high five insect cells by ATP consumption assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed