BDBM50332493 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)-N-hydroxythiophene-2-carboxamide::CHEMBL1630118

SMILES ONC(=O)c1ccc(s1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1

InChI Key InChIKey=DNZYOZKYEXTOPJ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50332493   

TargetInsulin receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of INSR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50: 940nMAssay Description:Inhibition of human recombinant HDAC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant HDAC6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50: 560nMAssay Description:Inhibition of Flag tagged human recombinant HDAC3 expressed in Sf21 cells coexpressing SMRT DAD domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50: 980nMAssay Description:Inhibition of Flag tagged human recombinant HDAC8 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of PDGFRbeta by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of ABL1 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of PLK1 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed