BDBM50332492 (E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)-N-hydroxyacrylamide::CHEMBL1630110

SMILES ONC(=O)\C=C\c1ccc(cc1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1

InChI Key InChIKey=QAQXTNHOYJTPGB-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50332492   

TargetInsulin receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of INSR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of Flag tagged human recombinant HDAC3 expressed in Sf21 cells coexpressing SMRT DAD domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50: 230nMAssay Description:Inhibition of human recombinant HDAC6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of Flag tagged human recombinant HDAC8 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50: 18nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50: 12nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of PDGFRbeta by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of ABL1 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50: 850nMAssay Description:Inhibition of CDK2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50: 650nMAssay Description:Inhibition of human recombinant HDAC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of PLK1 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed