BDBM50332459 ((2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate::CHEMBL1630001

SMILES C[C@]1([C@@H]([C@H](O[C@H]1n2cnc3c2N=C(NC3=O)N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)F

InChI Key InChIKey=GFEXCNGIPRYQFE-UHFFFAOYSA-N

Data  2 IC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50332459   

TargetNS5B(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50332459(((2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...)
Affinity DataIC50: 5.94E+3nMAssay Description:Inhibition of HCV NS5B polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50332459(((2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...)
Affinity DataIC50: 99nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed