BDBM50332292 (R)-5-((4-(3-hydroxypyridin-2-yl)phenyl)ethynyl)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)imidazolidine-2,4-dione::CHEMBL1288000::US8541572, 934

SMILES COc1ccc2CN(C[C@]3(NC(=O)NC3=O)C#Cc3ccc(cc3)-c3ncccc3O)C(=O)c2c1

InChI Key InChIKey=AUWCRYUPRHMNCJ-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50332292   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332292(US8541572, 934 | CHEMBL1288000 | (R)-5-((4-(3-hydr...)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50332292(US8541572, 934 | CHEMBL1288000 | (R)-5-((4-(3-hydr...)
Affinity DataKi:  0.0740nM IC50: 117nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2013
Entry Details
Go to US Patent