BDBM50331726 CHEMBL1289083::N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-phenylcyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide

SMILES CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@](O)(CC1)c1ccccc1

InChI Key InChIKey=KLHQJQIPLYZOOT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50331726   

TargetC-C chemokine receptor type 2(Mouse)
Incyte

Curated by ChEMBL
LigandPNGBDBM50331726(N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-phenylcy...)
Affinity DataIC50: 444nMAssay Description:Antagonist activity at mouse CCR2 assessed as inhibition of MCP1 induced chemotaxis after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50331726(N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-phenylcy...)
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]MCP1 from human CCR2 after 30 mins by gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Mouse)
Incyte

Curated by ChEMBL
LigandPNGBDBM50331726(N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-phenylcy...)
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]MCP1 from mouse CCR2 after 30 mins by gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50331726(N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-phenylcy...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human CCR2 assessed as inhibition of MCP1 induced chemotaxis after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
LigandPNGBDBM50331726(N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-phenylcy...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed