BDBM50331682 (2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2R)-1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylate::CHEMBL1289862

SMILES OC[C@@H](O)[C@@H](O)[C@@H]1OC(=C[C@H](O)[C@H]1NC(=O)CN=[N+]=[N-])C(O)=O

InChI Key InChIKey=OLOYDWMIOMMPCV-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50331682   

TargetSialidase-4(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50331682((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human NEU4 using 4-MU-NANA as substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSialidase-3(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50331682((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human NEU3 using 4-MU-NANA as substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSialidase-2(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50331682((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of human NEU2 using 4-MU-NANA as substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSialidase-1(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50331682((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human NEU1 using 4-MU-NANA as substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSialidase-3(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50331682((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human neuraminidase 3 assessed as inhibition of 4-methylumbelliferyl-alpha-D-glucopyranoside hydrolysis by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetSialidase-1(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50331682((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of human His6-tagged NEU1 expressed in HEK293 cells using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSialidase-2(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50331682((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSialidase-4(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50331682((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of MBP-fused human NEU4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSialidase-3(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50331682((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of N-terminal MBP-fused human NEU3 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSialidase-2(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50331682((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of NEU2 (unknown origin) using Neu5Acalpha2-3GalbetapNP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetSialidase-2(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50331682((2R,3R,4S)-3-(2-azidoacetamido)-4-hydroxy-2-((1R,2...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of NEU2 (unknown origin) using Neu5Acalpha2-6GalbetapNP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed