BDBM50331290 CHEMBL1289953::N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophen-2-ylmethyl)benzamide

SMILES Cc1cccc(c1)COc2ccccc2C(=O)N(CCCN)Cc3cccs3

InChI Key InChIKey=LCQJRANJHOEQFG-UHFFFAOYSA-N

Data  10 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50331290   

LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 160nMAssay Description:Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of menthol-induced 45calcium influx treated 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 190nMAssay Description:Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of icilin-induced 45calcium influx treated 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 4nMAssay Description:Inhibition of TRPM8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 414nMAssay Description:Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 448nMAssay Description:Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium increase by Fluo-4 AM based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 589nMAssay Description:Antagonist activity at human recombinant full length TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium increase preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 447nMAssay Description:Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium increase by Fluo-4 AM based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 6.50E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 7.30E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50331290(N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophe...)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at TRPM8 (unknown origin) assessed as reduction in calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)