BDBM50331069 (S)-6-chloro-5,7-dimethyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid::CHEMBL1288728

SMILES Cc1cc2O[C@@H](C(=Cc2c(C)c1Cl)C(O)=O)C(F)(F)F

InChI Key InChIKey=UNEVTVWOSGJGLU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50331069   

TargetProstaglandin G/H synthase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331069((S)-6-chloro-5,7-dimethyl-2-(trifluoromethyl)-2H-c...)
Affinity DataIC50: 2.28E+3nMAssay Description:Inhibition of human COX-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331069((S)-6-chloro-5,7-dimethyl-2-(trifluoromethyl)-2H-c...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant COX1 pre-incubated for 15 mins before fluorometric substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50331069((S)-6-chloro-5,7-dimethyl-2-(trifluoromethyl)-2H-c...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant COX2 pre-incubated for 15 mins before fluorometric substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50331069((S)-6-chloro-5,7-dimethyl-2-(trifluoromethyl)-2H-c...)
Affinity DataIC50: 46nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed