BDBM50331059 8-chloro-6-methyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid::CHEMBL1288566

SMILES Cc1cc(Cl)c2OC(C(=Cc2c1)C(O)=O)C(F)(F)F

InChI Key InChIKey=DIUCLSCBUOAEQY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50331059   

TargetProstaglandin G/H synthase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331059(8-chloro-6-methyl-2-(trifluoromethyl)-2H-chromene-...)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of human COX-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50331059(8-chloro-6-methyl-2-(trifluoromethyl)-2H-chromene-...)
Affinity DataIC50: 78nMAssay Description:Inhibition of human recombinant COX2 pre-incubated for 15 mins before fluorometric substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331059(8-chloro-6-methyl-2-(trifluoromethyl)-2H-chromene-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant COX1 pre-incubated for 15 mins before fluorometric substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50331059(8-chloro-6-methyl-2-(trifluoromethyl)-2H-chromene-...)
Affinity DataIC50: 63nMAssay Description:Inhibition of human recombinant COX2 pre-incubated for 15 mins before fluorometric substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50331059(8-chloro-6-methyl-2-(trifluoromethyl)-2H-chromene-...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed