BDBM50331058 6-chloro-8-methyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid::CHEMBL1288565

SMILES Cc1cc(Cl)cc2C=C(C(Oc12)C(F)(F)F)C(O)=O

InChI Key InChIKey=NONBXOPYDWLZGR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50331058   

TargetProstaglandin G/H synthase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331058(6-chloro-8-methyl-2-(trifluoromethyl)-2H-chromene-...)
Affinity DataIC50: 470nMAssay Description:Inhibition of human COX-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50331058(6-chloro-8-methyl-2-(trifluoromethyl)-2H-chromene-...)
Affinity DataIC50: 51nMAssay Description:Inhibition of human recombinant COX2 pre-incubated for 15 mins before fluorometric substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50331058(6-chloro-8-methyl-2-(trifluoromethyl)-2H-chromene-...)
Affinity DataIC50: 59nMAssay Description:Inhibition of human recombinant COX2 pre-incubated for 15 mins before fluorometric substrate addition by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50331058(6-chloro-8-methyl-2-(trifluoromethyl)-2H-chromene-...)
Affinity DataIC50: 84nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed