BDBM503308 6-amino-2-[(1R)-1-amino-8- azaspiro[4.5]decan-8-yl]-5-(2,3- dichlorophenyl)-pyrimidine-4- carboxamide::US11033547, Compound 7::US11696916, Compound 7

SMILES N[C@@H]1CCCC11CCN(CC1)c1nc(N)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O

InChI Key InChIKey=YIRKZPIRDBGPMD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503308   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503308(6-amino-2-[(1R)-1-amino-8- azaspiro[4.5]decan-8-yl...)
Affinity DataIC50: 120nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM503308(6-amino-2-[(1R)-1-amino-8- azaspiro[4.5]decan-8-yl...)
Affinity DataIC50: 120nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent