BDBM50330722 2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione::CHEMBL1276946::US12202790, Example GKT136901

SMILES Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12

InChI Key InChIKey=DNKYHHFCPXKFIY-UHFFFAOYSA-N

Data  4 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50330722   

TargetCytochrome P450 2C9(Human)
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataIC50: 2.09E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Glucox Biotech

US Patent
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataIC50: 1.60E+3nMAssay Description:Reactive oxygen produced in whole cells or in membrane preparation of Nox1, Nox3, Nox4, Nox5 and xanthine oxidase and glucose oxidase were determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetNADPH oxidase 1(Human)
Glucox Biotech

US Patent
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataIC50: 500nMAssay Description:Reactive oxygen produced in whole cells or in membrane preparation of Nox1, Nox3, Nox4, Nox5 and xanthine oxidase and glucose oxidase were determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetCytochrome b-245 heavy chain(Human)
Glucox Biotech

US Patent
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataIC50: 9.00E+3nMAssay Description:Reactive oxygen produced in whole cells or in membrane preparation of Nox1, Nox3, Nox4, Nox5 and xanthine oxidase and glucose oxidase were determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetNADPH oxidase 5(Human)
Glucox Biotech

US Patent
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataIC50: 4.40E+4nMAssay Description:Reactive oxygen produced in whole cells or in membrane preparation of Nox1, Nox3, Nox4, Nox5 and xanthine oxidase and glucose oxidase were determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetNADPH oxidase 4(Human)
Glucox Biotech

US Patent
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataKi:  165nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 1(Human)
Glucox Biotech

US Patent
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataKi:  165nMAssay Description:Inhibition of human NOX1 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome b-245 heavy chain(Human)
Glucox Biotech

US Patent
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataKi:  1.53E+3nMAssay Description:Inhibition of human NOX2 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of xanthine oxidase by in vitro enzymatic assay in presence of xanthineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed