BDBM50330347 6-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-2-(3,5-difluoro-phenyl)-4-(3-methoxy-propyl)-2-methyl-4Hbenzo[1,4]oxazin-3-one::CHEMBL239496::rac-6-(2,4-diamino-6-ethylpyrimidin-5-yl)-2-(3,5-difluorophenyl)-4-(3-methoxypropyl)-2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one

SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCCOC)c2c1)c1cc(F)cc(F)c1

InChI Key InChIKey=UAXNNGUDPWZOKX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50330347   

TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330347(6-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-2-(3,5-difl...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330347(6-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-2-(3,5-difl...)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of human reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330347(6-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-2-(3,5-difl...)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details Article
PubMed