BDBM50330291 CHEMBL1272327::[4-(3-Isopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-piperidin-4-ylamine

SMILES CC(C)c1[nH]ncc1-c1ccnc(NC2CCNCC2)n1

InChI Key InChIKey=JKOBDZOYRWHJIV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50330291   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330291([4-(3-Isopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-p...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human CDK4/cyclin D1 expressed in baculovirus infected Sf21 cells after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330291([4-(3-Isopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-p...)
Affinity DataIC50: 828nMAssay Description:Inhibition of human CDK2/cyclin A after 2 hrs by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330291([4-(3-Isopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-p...)
Affinity DataIC50: 492nMAssay Description:Inhibition of human CDK1/cyclin B after 2 hrs by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed