BDBM50330275 CHEMBL1271671::[4-(3-Cyclopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-(5-piperazin-1-yl-pyridin-2-yl)amine

SMILES C1CC1c1[nH]ncc1-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1

InChI Key InChIKey=VYJAEGLVFKBLFQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50330275   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330275([4-(3-Cyclopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]...)
Affinity DataIC50: 89nMAssay Description:Inhibition of human CDK4/cyclin D1 expressed in baculovirus infected Sf21 cells after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330275([4-(3-Cyclopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]...)
Affinity DataIC50: 1.56E+4nMAssay Description:Inhibition of human CDK2/cyclin A after 2 hrs by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330275([4-(3-Cyclopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human CDK1/cyclin B after 2 hrs by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed