BDBM50329935 1-methyl-8-(5-(2-(1-methylpyrrolidin-2-yl)ethylamino)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271535

SMILES CN1CCCC1CCNc1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1

InChI Key InChIKey=JVZPJOJXJIONKU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50329935   

TargetSerine/threonine-protein kinase PLK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329935(1-methyl-8-(5-(2-(1-methylpyrrolidin-2-yl)ethylami...)
Affinity DataIC50: 429nMAssay Description:Inhibition of PLK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329935(1-methyl-8-(5-(2-(1-methylpyrrolidin-2-yl)ethylami...)
Affinity DataIC50: 485nMAssay Description:Inhibition of PLK3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329935(1-methyl-8-(5-(2-(1-methylpyrrolidin-2-yl)ethylami...)
Affinity DataIC50: 149nMAssay Description:Inhibition of PLK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329935(1-methyl-8-(5-(2-(1-methylpyrrolidin-2-yl)ethylami...)
Affinity DataIC50: 123nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329935(1-methyl-8-(5-(2-(1-methylpyrrolidin-2-yl)ethylami...)
Affinity DataIC50: 429nMAssay Description:Inhibition of PLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329935(1-methyl-8-(5-(2-(1-methylpyrrolidin-2-yl)ethylami...)
Affinity DataIC50: 485nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329935(1-methyl-8-(5-(2-(1-methylpyrrolidin-2-yl)ethylami...)
Affinity DataIC50: 969nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed