BDBM50329930 CHEMBL1269487::tert-butyl 4-(3-(3-carbamoyl-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazolin-8-ylamino)-4-(trifluoromethoxy)phenyl)piperazine-1-carboxylate

SMILES Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCN(CC4)C(=O)OC(C)(C)C)nc3-c12

InChI Key InChIKey=QANJTFCNOSLQBM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50329930   

TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329930(tert-butyl 4-(3-(3-carbamoyl-1-methyl-4,5-dihydro-...)
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329930(tert-butyl 4-(3-(3-carbamoyl-1-methyl-4,5-dihydro-...)
Affinity DataIC50: 262nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329930(tert-butyl 4-(3-(3-carbamoyl-1-methyl-4,5-dihydro-...)
Affinity DataIC50: 768nMAssay Description:Inhibition of PLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329930(tert-butyl 4-(3-(3-carbamoyl-1-methyl-4,5-dihydro-...)
Affinity DataIC50: 859nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed