BDBM50329915 1-methyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271644

SMILES Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCNCC4)nc3-c12

InChI Key InChIKey=TUWAYASUNDRSML-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50329915   

TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50329915(1-methyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy...)
Affinity DataIC50: 2nMpH: 7.9Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase PLK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329915(1-methyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329915(1-methyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329915(1-methyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329915(1-methyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy...)
Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50329915(1-methyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329915(1-methyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy...)
Affinity DataIC50: 595nMAssay Description:Inhibition of NEK6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50329915(1-methyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy...)
Affinity DataIC50: 194nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed