BDBM50329704 (R)-3-(4-(3-(4-((R)-2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-2-methylphenoxy)propane-1,2-diol::CHEMBL403670

SMILES CCC(CC)(c1ccc(OC[C@H](O)CO)c(C)c1)c1ccc(OC[C@H](O)C(C)(C)C)c(C)c1

InChI Key InChIKey=AIKLCYAFOOBGEV-UHFFFAOYSA-N

Data  2 KI  3 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50329704   

TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50329704((R)-3-(4-(3-(4-((R)-2-hydroxy-3,3-dimethylbutoxy)-...)
Affinity DataEC50:  26nMAssay Description:Vitamin-D activity at VDR receptor in human HL60 cells assessed as induction of cell differentiation by NBT reduction assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50329704((R)-3-(4-(3-(4-((R)-2-hydroxy-3,3-dimethylbutoxy)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50329704((R)-3-(4-(3-(4-((R)-2-hydroxy-3,3-dimethylbutoxy)-...)
Affinity DataEC50:  40nMAssay Description:Agonist activity at VDR (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50329704((R)-3-(4-(3-(4-((R)-2-hydroxy-3,3-dimethylbutoxy)-...)
Affinity DataEC50:  4.68nMAssay Description:Effect on VDR transcriptional activity in human osteosarcoma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50329704((R)-3-(4-(3-(4-((R)-2-hydroxy-3,3-dimethylbutoxy)-...)
Affinity DataEC50:  16.8nMAssay Description:Effect on VDR transcriptional activity in human osteosarcoma cells in presence of 5% fetal calf serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50329704((R)-3-(4-(3-(4-((R)-2-hydroxy-3,3-dimethylbutoxy)-...)
Affinity DataEC50:  22.1nMAssay Description:Effect on VDR transcriptional activity in human Caco-2 cells in presence of 5% fetal calf serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Mouse)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50329704((R)-3-(4-(3-(4-((R)-2-hydroxy-3,3-dimethylbutoxy)-...)
Affinity DataIC50: 19nMAssay Description:Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Mouse)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50329704((R)-3-(4-(3-(4-((R)-2-hydroxy-3,3-dimethylbutoxy)-...)
Affinity DataIC50: 14nMAssay Description:Antiandrogen activity against androgen receptor in androgen-dependent mouse SC3 cells assessed as inhibition of testosterone-induced cell proliferati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50329704((R)-3-(4-(3-(4-((R)-2-hydroxy-3,3-dimethylbutoxy)-...)
Affinity DataKi:  320nMAssay Description:Binding affinity to VDR receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50329704((R)-3-(4-(3-(4-((R)-2-hydroxy-3,3-dimethylbutoxy)-...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed