BDBM50329649 1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate::CHEMBL1270841

SMILES CC(OC(=O)c1cc2c(cn1)[nH]c1ccccc21)c1ccccc1

InChI Key InChIKey=FKRRGAJQEMJONC-UHFFFAOYSA-N

Data  12 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50329649   

TargetGamma-aminobutyric acid receptor subunit alpha-6(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant GABAA alpha6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant GABAA alpha5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant GABAA alpha4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant GABAA alpha3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant GABAA alpha2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant GABAA alpha1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataKi:  33.5nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-1-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataKi:  34nMAssay Description:Binding affinity to human recombinant GABAA alpha1 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to human recombinant GABAA alpha4 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to human recombinant GABAA alpha5 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to human recombinant GABAA alpha3 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to human recombinant GABAA alpha2 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-5-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGABA A receptor alpha-4/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-4-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-3-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-2-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity to human recombinant GABAA alpha6 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataKi:  3.00E+3nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-6-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed