BDBM50329558 (R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-fluoro-3-(3-fluoropropoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1270029

SMILES CN1C(N)=N[C@](C1=O)(c1ccc(OC(F)F)cc1)c1ccc(F)c(OCCCF)c1

InChI Key InChIKey=ZPKMNSUSQSIWHS-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50329558   

TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329558((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataEC50:  40nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329558((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329558((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50: 280nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCathepsin D(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329558((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50: 2.98E+3nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetRenin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329558((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of renin by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed